The humans are occasionally aided by angels, notably the Archangel Tyrael. The series primarily focuses on the ongoing conflict between the humans living in Sanctuary and the demon hordes who are led by Diablo, the series' overarching antagonist. Other notable settings include the High Heavens and the Burning Hells, two separate realms with ties to Sanctuary.

The first three games in the series take place in similar geographic areas, with several common areas including the town of Tristram and the region around Mount Arreat. The series is set in the dark fantasy world of Sanctuary, and its characters are primarily humans, angels, and various classes of demons and monsters.

Additional content is provided through story elements explored in other media forms. Expansions include the third-party published Hellfire, which follows the first game Lord of Destruction, published by Blizzard and released after the second game and Reaper of Souls, which follows the third game. The series is made up of four core games: Diablo, Diablo II, Diablo III, and Diablo IV. Microsoft Windows, Classic Mac OS, macOS, PlayStation, PlayStation 3, PlayStation 4, Xbox 360, Xbox One, Nintendo Switch, PlayStation 5, Xbox Series X/S, Android, iOSĭiablo is an action role-playing dungeon crawler video game series developed by Blizzard North and continued by Blizzard Entertainment after the North studio shutdown in 2005.

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